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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 8, 2050-2053

https://doi.org/10.37358/RC.18.8.6471

Gabriela Jimborean, Oana Cristina Arghir, Simona Claudia Cambrea, Elena Dantes, Adriana Socaci, Marina Ruxandra Otelea, Edwin Sever Bechir, Edith Simona Ianosi

The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease

Abstract:

In the evolution of patients with chronic obstructive pulmonary disease (COPD), exacerbations occur, especially, in severe stages, determining aggravated respiratory failure and decreased survival. In order to evaluate the implications of COPD exacerbations in patients with second type of chronic respiratory failure and hypercapnic encephalopathy, a prospective observational study was done among 195 COPD in patients of Targu Mures Clinical County Hospital, Romania. Inclusion criteria consisted in severe exacerbations of COPD, complicated by hypercapnia, defined by an increased level of arterial blood gas carbon dioxide (PaCO2) ³45 mmHg, suggestive for the second type of respiratory failure. The increased values of PaCO2 ranged between 45 and 112 mmHg among 95 patients. The prevalence of hypercapnia in COPD patients, admitted in hospital for severe exacerbations, was high (n=91/195; 46.66%). The majority of COPD patients (93.4%) were initially hospitalized in the intensive care unit (ICU) department because of hypercapnic encephalopathy. The mortality rate was higher among patients with endotracheal tube insertion than in patients treated by noninvasive mechanical ventilation. High levels of hypercapnia, conscience disorders and respiratory acidosis may be considered factors of severity in COPD exacerbation.
Keywords:
PaCO2; COPD; exacerbation; hypercapnia; respiratory failure; hypercapnic encephalopathy

Issue: 2018, Volume 69, Issue 8
Pages: 2050-2053
Publication date: 2018/9/15
https://doi.org/10.37358/RC.18.8.6471
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
JIMBOREAN, G., ARGHIR, O.C., CAMBREA, S.C., DANTES, E., SOCACI, A., OTELEA, M.R., BECHIR, E.S., IANOSI, E.S., The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease, Rev. Chim., 69(8), 2018, 2050-2053.

Vancouver
Jimborean G, Arghir OC, Cambrea SC, Dantes E, Socaci A, Otelea MR, Bechir ES, Ianosi ES. The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease. Rev. Chim.[internet]. 2018 Aug;69(8):2050-2053. Available from: https://doi.org/10.37358/RC.18.8.6471


APA 6th edition
Jimborean, G., Arghir, O.C., Cambrea, S.C., Dantes, E., Socaci, A., Otelea, M.R., Bechir, E.S. & Ianosi, E.S. (2018). The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease. Revista de Chimie, 69(8), 2050-2053. https://doi.org/10.37358/RC.18.8.6471


Harvard
Jimborean, G., Arghir, O.C., Cambrea, S.C., Dantes, E., Socaci, A., Otelea, M.R., Bechir, E.S., Ianosi, E.S. (2018). 'The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease', Revista de Chimie, 69(8), pp. 2050-2053. https://doi.org/10.37358/RC.18.8.6471


IEEE
G. Jimborean, O.C. Arghir, S.C. Cambrea, E. Dantes, A. Socaci, M.R. Otelea, E.S. Bechir, E.S. Ianosi, "The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease". Revista de Chimie, vol. 69, no. 8, pp. 2050-2053, 2018. [online]. https://doi.org/10.37358/RC.18.8.6471


Text
Gabriela Jimborean, Oana Cristina Arghir, Simona Claudia Cambrea, Elena Dantes, Adriana Socaci, Marina Ruxandra Otelea, Edwin Sever Bechir, Edith Simona Ianosi,
The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2050-2053,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6471.
(https://revistadechimie.ro/Articles.asp?ID=6471)
Keywords: PaCO2; COPD; exacerbation; hypercapnia; respiratory failure; hypercapnic encephalopathy


RIS
TY - JOUR
T1 - The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease
A1 - Jimborean, Gabriela
A2 - Arghir, Oana Cristina
A3 - Cambrea, Simona Claudia
A4 - Dantes, Elena
A5 - Socaci, Adriana
A6 - Otelea, Marina Ruxandra
A7 - Bechir, Edwin Sever
A8 - Ianosi, Edith Simona
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2050
EP - 2053
UR - https://doi.org/10.37358/RC.18.8.6471
KW - PaCO2
KW - COPD
KW - exacerbation
KW - hypercapnia
KW - respiratory failure
KW - hypercapnic encephalopathy
ER -


BibTex
@article{RevCh2018P2050,
author = {Jimborean Gabriela and Arghir Oana Cristina and Cambrea Simona Claudia and Dantes Elena and Socaci Adriana and Otelea Marina Ruxandra and Bechir Edwin Sever and Ianosi Edith Simona},
title = {The Clinical Implications of Carbon Dioxide Increased Level in Arterial Blood Related to Severe Exacerbations of Chronic Obstructive Pulmonary Disease},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2050-2053},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6471},
url = {https://revistadechimie.ro/Articles.asp?ID=6471}
}
 
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