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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 8, 2025-2028

https://doi.org/10.37358/RC.18.8.6466

Ana Simona Drochioi, Dan Cristian Moraru, Ilie Cristian Drochioi, Magdalena Iorga, Eduard Crauciuc, Evelina Moraru

The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C

Abstract:

The liver is the main metabolic organ, having complex physiological and biochemical roles, many of these functions being in a close relationship. It is also well known that hepatitis C virus infection is associated with changes in lipid metabolism. This is evident in liver dysfunctions, when liver functions are disturbed simultaneously. The aim of this study is to evaluate the effect of antiviral therapy on serum lipid level in patients with viral hepatitis C before and at the end of the 48 weeks of treatment compared patients treated with Interferon vs Interferon + Ribavirin and relation with sustained virological response, from North East Romania. We evaluated patients hospitalized in Emergency Hospital for Children St. Mary Iasi between 2009-2017. The result of our study show that the mean age of patients from goup 1 was 11.85±3.65 years, vs 11.5±3.1 years in group 2 (p=0.171). We found changes in cholesterol metabolism in both groups of patients, increases in total cholesterol level, 21.43% of patients in the group 1 vs 32.3% in goup 2 (p=0.258) and decreases 17.86% vs 14.7% (p=0.131). At initiation of antiviral therapy mean serum cholesterol level were 155.78±36.30 mg/dL, in group 1 vs 149.88±47.22 mg/dL, for group 2. At 48 weeks of treatment in the both goups revealed significantly decreased of total cholesterol levels 136.46±41.63mg/dL, for group 1 vs 109.26±41.05, for patients in group 2 (p=0.003). Triglycerides, HDL cholesterol and LDL cholesterol did not show significant changes in the patients of the two groups. Total cholesterol level after antiviral therapy were significantly different between patients who achieved SVR and non SVR (p=0.014), group 1 vs (p=0.001), group 2. Total serum cholesterol level showed significant changes during the antiviral therapy in both monotherapy and combination therapy group.
Keywords:
viral hepatitis C; cholesterol; trygliceride; antiviral therapy

Issue: 2018, Volume 69, Issue 8
Pages: 2025-2028
Publication date: 2018/9/15
https://doi.org/10.37358/RC.18.8.6466
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DROCHIOI, A.S., MORARU, D.C., DROCHIOI, I.C., IORGA, M., CRAUCIUC, E., MORARU, E., The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C, Rev. Chim., 69(8), 2018, 2025-2028.

Vancouver
Drochioi AS, Moraru DC, Drochioi IC, Iorga M, Crauciuc E, Moraru E. The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C. Rev. Chim.[internet]. 2018 Aug;69(8):2025-2028. Available from: https://doi.org/10.37358/RC.18.8.6466


APA 6th edition
Drochioi, A.S., Moraru, D.C., Drochioi, I.C., Iorga, M., Crauciuc, E. & Moraru, E. (2018). The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C. Revista de Chimie, 69(8), 2025-2028. https://doi.org/10.37358/RC.18.8.6466


Harvard
Drochioi, A.S., Moraru, D.C., Drochioi, I.C., Iorga, M., Crauciuc, E., Moraru, E. (2018). 'The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C', Revista de Chimie, 69(8), pp. 2025-2028. https://doi.org/10.37358/RC.18.8.6466


IEEE
A.S. Drochioi, D.C. Moraru, I.C. Drochioi, M. Iorga, E. Crauciuc, E. Moraru, "The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C". Revista de Chimie, vol. 69, no. 8, pp. 2025-2028, 2018. [online]. https://doi.org/10.37358/RC.18.8.6466


Text
Ana Simona Drochioi, Dan Cristian Moraru, Ilie Cristian Drochioi, Magdalena Iorga, Eduard Crauciuc, Evelina Moraru,
The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2025-2028,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6466.
(https://revistadechimie.ro/Articles.asp?ID=6466)
Keywords: viral hepatitis C; cholesterol; trygliceride; antiviral therapy


RIS
TY - JOUR
T1 - The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C
A1 - Drochioi, Ana Simona
A2 - Moraru, Dan Cristian
A3 - Drochioi, Ilie Cristian
A4 - Iorga, Magdalena
A5 - Crauciuc, Eduard
A6 - Moraru, Evelina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2025
EP - 2028
UR - https://doi.org/10.37358/RC.18.8.6466
KW - viral hepatitis C
KW - cholesterol
KW - trygliceride
KW - antiviral therapy
ER -


BibTex
@article{RevCh2018P2025,
author = {Drochioi Ana Simona and Moraru Dan Cristian and Drochioi Ilie Cristian and Iorga Magdalena and Crauciuc Eduard and Moraru Evelina},
title = {The Effect of Antiviral Therapy on Lipid Metabolism in Patients with Viral Hepatitis C},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2025-2028},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6466},
url = {https://revistadechimie.ro/Articles.asp?ID=6466}
}
 
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