Chemical Effects and Predictive Factors in Premature Birth

Neacsu, Adrian; Calin, Alina; Braila, Anca Daniela; Navolan, Dan; Dimitriu, Mihai; Stanica, Catalina Diana; Ioan, Raluca; Ionescu, Cringu

Adrian Neacsu, Alina Calin, Anca Daniela Braila, Dan Navolan, Mihai Dimitriu, Catalina Diana Stanica, Raluca Ioan, Cringu Ionescu

Chemical Effects and Predictive Factors in Premature Birth

Abstract:

Premature birth is considered to be the consequence of independent alterations in the cervix and in the uterus. During labor, for full-term birth, as well as for premature birth, the cervix changes, from firm, long and closed, to soft and pliable, through a biochemical process characterized by the reshaping of the extracellular matrix and a growth of the tissue concentration of inflammatory mediators; the uterus proves an increase in contractility and sensitivity to endogenic hormones, such as oxytocin. Premature labor is associated with the premature activation of the release of cytokines in the decidua (mucosa lining uterus walls) and cervix. Interleukins IL-1 beta, IL-6, IL-8 and the alpha tumoral necrosis factor increase the production and activation of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9) and of cathepsin S, which digests the collagen from the extracellular matrix of the cervix, causing the wiping and softening of the cervix. These cytokines are released by leukocytes in the myometer, leading to the production of prostaglandins and oxytocin, which stimulate uterine contractions. Therefore, the cervical shortening represented by ultrasound is believed to represent premature cervical softening. The obstetrical approach of aspects related to premature birth are based, considerably, on the prognosis expected by the obstetrician regarding the survival of the premature new-born baby, as well as the therapeutic variants to be followed. And not only survival is important, of equal importance is also the quality of life of underweight, immature new-born babies, who are considerably affected both physically, and intellectually.

Keywords:
premature birth; ultrasound markers; biochemical markers; predictive markers

Issue: 2018, Volume 69, Issue 7

Pages: 1796-1801

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6419

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NEACSU, A., CALIN, A., BRAILA, A.D., NAVOLAN, D., DIMITRIU, M., STANICA, C.D., IOAN, R., IONESCU, C., Chemical Effects and Predictive Factors in Premature Birth, Rev. Chim., 69(7), 2018, 1796-1801.

Vancouver
Neacsu A, Calin A, Braila AD, Navolan D, Dimitriu M, Stanica CD, Ioan R, Ionescu C. Chemical Effects and Predictive Factors in Premature Birth. Rev. Chim.[internet]. 2018 Jul;69(7):1796-1801. Available from: https://doi.org/10.37358/RC.18.7.6419

APA 6th edition
Neacsu, A., Calin, A., Braila, A.D., Navolan, D., Dimitriu, M., Stanica, C.D., Ioan, R. & Ionescu, C. (2018). Chemical Effects and Predictive Factors in Premature Birth. Revista de Chimie, 69(7), 1796-1801. https://doi.org/10.37358/RC.18.7.6419

Harvard
Neacsu, A., Calin, A., Braila, A.D., Navolan, D., Dimitriu, M., Stanica, C.D., Ioan, R., Ionescu, C. (2018). 'Chemical Effects and Predictive Factors in Premature Birth', Revista de Chimie, 69(7), pp. 1796-1801. https://doi.org/10.37358/RC.18.7.6419

IEEE
A. Neacsu, A. Calin, A.D. Braila, D. Navolan, M. Dimitriu, C.D. Stanica, R. Ioan, C. Ionescu, "Chemical Effects and Predictive Factors in Premature Birth". Revista de Chimie, vol. 69, no. 7, pp. 1796-1801, 2018. [online]. https://doi.org/10.37358/RC.18.7.6419

Text
Adrian Neacsu, Alina Calin, Anca Daniela Braila, Dan Navolan, Mihai Dimitriu, Catalina Diana Stanica, Raluca Ioan, Cringu Ionescu,
Chemical Effects and Predictive Factors in Premature Birth,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1796-1801,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6419.
(https://revistadechimie.ro/Articles.asp?ID=6419)
Keywords: premature birth; ultrasound markers; biochemical markers; predictive markers

RIS
TY - JOUR
T1 - Chemical Effects and Predictive Factors in Premature Birth
A1 - Neacsu, Adrian
A2 - Calin, Alina
A3 - Braila, Anca Daniela
A4 - Navolan, Dan
A5 - Dimitriu, Mihai
A6 - Stanica, Catalina Diana
A7 - Ioan, Raluca
A8 - Ionescu, Cringu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1796
EP - 1801
UR - https://doi.org/10.37358/RC.18.7.6419
KW - premature birth
KW - ultrasound markers
KW - biochemical markers
KW - predictive markers
ER -

BibTex
@article{RevCh2018P1796,
author = {Neacsu Adrian and Calin Alina and Braila Anca Daniela and Navolan Dan and Dimitriu Mihai and Stanica Catalina Diana and Ioan Raluca and Ionescu Cringu},
title = {Chemical Effects and Predictive Factors in Premature Birth},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1796-1801},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6419},
url = {https://revistadechimie.ro/Articles.asp?ID=6419}
}

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