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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 6, 1570-1573

https://doi.org/10.37358/RC.18.6.6371

Decebal Vasincu, Roxana Irina Iancu, Liliana Chelaru, Gabriela Stoleriu, Marcel Costuleanu

Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro

Abstract:

Our studies aimed the effects of some endoplasmic reticulum stress inducers (thapsigargin, a Ca2+-ATP-ase inhibitor; tunicamycin, a protein N-glycosylation inhibitor; brefeldin A, a protein transport inhibitor; paraquat, an enhancer of reactive oxygen species production; A23187, a Ca2+ ionophore), as well as some antioxidants (N-acetylcysteine; dithiothreitol, a disulfide bond formation inhibitor) on apoptosis of cultured rat mesenchymal stem cells. The analyze of obtained results evidenced that paraquat, a common and effective herbicide, induced the apoptosis of the isolated rat mesenchymal stem cells in a larger proportion as compared to other chemicals as follows: paraquat ] thapsigargin ] tunicamycin @A23187 ] brefeldin A. Dithiothreitol was effective as a reducer of mesenchymal stem cells apoptosis when was administered as co-treatment for paraquat for 24 h. In contrast, N-acetylcysteine, another potent antioxidant, had no protective effects against paraquat apoptotic effects.
Keywords:
mesenchymal stem cell; rat; paraquat; thapsigargin; dithiothreitol

Issue: 2018, Volume 69, Issue 6
Pages: 1570-1573
Publication date: 2018/7/15
https://doi.org/10.37358/RC.18.6.6371
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
VASINCU, D., IANCU, R.I., CHELARU, L., STOLERIU, G., COSTULEANU, M., Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro, Rev. Chim., 69(6), 2018, 1570-1573.

Vancouver
Vasincu D, Iancu RI, Chelaru L, Stoleriu G, Costuleanu M. Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro. Rev. Chim.[internet]. 2018 Jun;69(6):1570-1573. Available from: https://doi.org/10.37358/RC.18.6.6371


APA 6th edition
Vasincu, D., Iancu, R.I., Chelaru, L., Stoleriu, G. & Costuleanu, M. (2018). Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro. Revista de Chimie, 69(6), 1570-1573. https://doi.org/10.37358/RC.18.6.6371


Harvard
Vasincu, D., Iancu, R.I., Chelaru, L., Stoleriu, G., Costuleanu, M. (2018). 'Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro', Revista de Chimie, 69(6), pp. 1570-1573. https://doi.org/10.37358/RC.18.6.6371


IEEE
D. Vasincu, R.I. Iancu, L. Chelaru, G. Stoleriu, M. Costuleanu, "Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro". Revista de Chimie, vol. 69, no. 6, pp. 1570-1573, 2018. [online]. https://doi.org/10.37358/RC.18.6.6371


Text
Decebal Vasincu, Roxana Irina Iancu, Liliana Chelaru, Gabriela Stoleriu, Marcel Costuleanu,
Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1570-1573,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6371.
(https://revistadechimie.ro/Articles.asp?ID=6371)
Keywords: mesenchymal stem cell; rat; paraquat; thapsigargin; dithiothreitol


RIS
TY - JOUR
T1 - Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro
A1 - Vasincu, Decebal
A2 - Iancu, Roxana Irina
A3 - Chelaru, Liliana
A4 - Stoleriu, Gabriela
A5 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1570
EP - 1573
UR - https://doi.org/10.37358/RC.18.6.6371
KW - mesenchymal stem cell
KW - rat
KW - paraquat
KW - thapsigargin
KW - dithiothreitol
ER -


BibTex
@article{RevCh2018P1570,
author = {Vasincu Decebal and Iancu Roxana Irina and Chelaru Liliana and Stoleriu Gabriela and Costuleanu Marcel},
title = {Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1570-1573},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6371},
url = {https://revistadechimie.ro/Articles.asp?ID=6371}
}
 
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