Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders

Duica, Lavinia; Antonescu, Elisabeta; Pirlog, Mihail; Purnichi, Traian; Szakacs, Julianna; Totan, Maria; Vintila, Bogdan Ioan; Mitariu, Mihaela Cernusca; Mitariu, Sebastian Ioan Cernusca; Stetiu, Andreea; Bota, Gabriela; Bereanu, Alina; Manea, Marinela Minodora

Lavinia Duica, Elisabeta Antonescu, Mihail Pirlog, Traian Purnichi, Julianna Szakacs, Maria Totan, Bogdan Ioan Vintila, Mihaela Cernusca Mitariu, Sebastian Ioan Cernusca Mitariu, Andreea Stetiu, Gabriela Bota, Alina Bereanu, Marinela Minodora Manea

Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders

Abstract:

Hyperdopaminergia has been identified at impulsive or psychotic patients, the polymorphism of COMT or other enzymes that metabolize dopamine could be involved. The deficiencies of the serotoninergic system in suicidal behaviour has been mentioned by many studies that indicate the reduction of 5-HT, 5-HIAA in CSF or 5-HTT polymorphism. Young patients with psychotic or depression symptoms manifest, frequently, aggressive and self-harm behaviour. Besides the association between the young age and the aggressivity of the patients with serious mental disorders, our study shows gender differences and this matter is sustained by hormonal factors. The study was conducted at the Gheorghe Preda Psychiatric Hospital in Sibiu. The study comprises 52 patients aged between 18 and 35 who were diagnosed with the diagnosis of Schizophrenia, Bipolar Affective Disorder, Depressive Episode and Major depressive disorder according to the DSM-5 criteria. Evaluation of the severity of psychiatric and depressive symptomathology were assessed with Brief Psychiatric Rating Scale and Beck Depression Inventory; aggression and self-aggression in the patients with Schizophrenia, respectively with Bipolar disorder, depressive episode and Major depression disorder were assessed with Buss Perry Aggression Questionnaire and Suicide Intent Scale. Regarding the severity of aggression in the young patients from our study (Buss Perry scale score), male gender is higher than female gender: higher percentages in males (35% and 10%) than in females (16 and 0%). Determining aggression in schizophrenia is possible due to COMT polymorphism that lead to impulsivity or psychotic symptoms. The study show a significant positive correlation between the severity of symptoms of schizophrenia and aggression. From the analysis of the severity of depression in young patients (SIS score) it is noted that its severity is higher in the female gender. Women had higher scores of moderate depression (58%) and severe (26%) than men (37 and 25%, respectively). This relationships could be possible due to the polymorphism of the gene encoding the 5-HTT serotonin transporter related with serotonin deficiency.The study do not show a significant positive correlation between the severity of the depressive symptomatology and the degree of the suicide intent.

Keywords:
aggression; depression; young patients; biological marker; mental disorders

Issue: 2018, Volume 69, Issue 6

Pages: 1544-1549

Publication date: 2018/7/15

https://doi.org/10.37358/RC.18.6.6365

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DUICA, L., ANTONESCU, E., PIRLOG, M., PURNICHI, T., SZAKACS, J., TOTAN, M., VINTILA, B.I., MITARIU, M.C., MITARIU, S.I.C., STETIU, A., BOTA, G., BEREANU, A., MANEA, M.M., Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders, Rev. Chim., 69(6), 2018, 1544-1549.

Vancouver
Duica L, Antonescu E, Pirlog M, Purnichi T, Szakacs J, Totan M, Vintila BI, Mitariu MC, Mitariu SIC, Stetiu A, Bota G, Bereanu A, Manea MM. Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders. Rev. Chim.[internet]. 2018 Jun;69(6):1544-1549. Available from: https://doi.org/10.37358/RC.18.6.6365

APA 6th edition
Duica, L., Antonescu, E., Pirlog, M., Purnichi, T., Szakacs, J., Totan, M.,... Manea, M.M. (2018). Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders. Revista de Chimie, 69(6), 1544-1549. https://doi.org/10.37358/RC.18.6.6365

Harvard
Duica, L., Antonescu, E., Pirlog, M., Purnichi, T., Szakacs, J., Totan, M., Vintila, B.I., Mitariu, M.C., Mitariu, S.I.C., Stetiu, A., Bota, G., Bereanu, A., Manea, M.M. (2018). 'Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders', Revista de Chimie, 69(6), pp. 1544-1549. https://doi.org/10.37358/RC.18.6.6365

IEEE
L. Duica, E. Antonescu, M. Pirlog, T. Purnichi, J. Szakacs, M. Totan, B.I. Vintila, M.C. Mitariu, S.I.C. Mitariu, A. Stetiu, G. Bota, A. Bereanu, M.M. Manea, "Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders". Revista de Chimie, vol. 69, no. 6, pp. 1544-1549, 2018. [online]. https://doi.org/10.37358/RC.18.6.6365

Text
Lavinia Duica, Elisabeta Antonescu, Mihail Pirlog, Traian Purnichi, Julianna Szakacs, Maria Totan, Bogdan Ioan Vintila, Mihaela Cernusca Mitariu, Sebastian Ioan Cernusca Mitariu, Andreea Stetiu, Gabriela Bota, Alina Bereanu, Marinela Minodora Manea,
Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1544-1549,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6365.
(https://revistadechimie.ro/Articles.asp?ID=6365)
Keywords: aggression; depression; young patients; biological marker; mental disorders

RIS
TY - JOUR
T1 - Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders
A1 - Duica, Lavinia
A2 - Antonescu, Elisabeta
A3 - Pirlog, Mihail
A4 - Purnichi, Traian
A5 - Szakacs, Julianna
A6 - Totan, Maria
A7 - Vintila, Bogdan Ioan
A8 - Mitariu, Mihaela Cernusca
A9 - Mitariu, Sebastian Ioan Cernusca
A10 - Stetiu, Andreea
A11 - Bota, Gabriela
A12 - Bereanu, Alina
A13 - Manea, Marinela Minodora
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1544
EP - 1549
UR - https://doi.org/10.37358/RC.18.6.6365
KW - aggression
KW - depression
KW - young patients
KW - biological marker
KW - mental disorders
ER -

BibTex
@article{RevCh2018P1544,
author = {Duica Lavinia and Antonescu Elisabeta and Pirlog Mihail and Purnichi Traian and Szakacs Julianna and Totan Maria and Vintila Bogdan Ioan and Mitariu Mihaela Cernusca and Mitariu Sebastian Ioan Cernusca and Stetiu Andreea and Bota Gabriela and Bereanu Alina and Manea Marinela Minodora},
title = {Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1544-1549},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6365},
url = {https://revistadechimie.ro/Articles.asp?ID=6365}
}

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