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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 6, 1501-1505

https://doi.org/10.37358/RC.18.6.6355

Roxana Maria Livadariu, Radu Danila, Lidia Ionescu, Delia Ciobanu, Daniel Timofte

Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity

Abstract:

Nonalcoholic fatty liver disease (NAFLD) is highly associated to obesity and comprises several liver diseases, from simple steatosis to steatohepatitis (NASH) with increased risk of developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma. Liver biopsy is the gold standard in diagnosing the disease, but it cannot be used in a large scale. The aim of the study was the assessment of some non-invasive clinical and biological markers in relation to the progressive forms of NAFLD. We performed a prospective study on 64 obese patients successively hospitalised for bariatric surgery in our Surgical Unit. Patients with history of alcohol consumption, chronic hepatitis B or C, other chronic liver disease or patients undergoing hepatotoxic drug use were excluded. All patients underwent liver biopsy during sleeve gastrectomy. NAFLD was present in 100% of the patients: hepatic steatosis (38%), NASH with the two forms: with fibrosis (31%) and without fibrosis (20%), cumulating 51%; 7 patients had NASH with vanished steatosis. NASH with fibrosis statistically correlated with metabolic syndrome (p = 0.036), DM II (p = 0.01) and obstructive sleep apnea (p = 0.02). Waist circumference was significantly higher in the steatohepatitis groups (both with and without fibrosis), each 10 cm increase increasing the risk of steatohepatitis (p = 0.007). The mean values of serum fibrinogen and CRP were significantly higher in patients having the progressive forms of NAFLD. Simple clinical and biological data available to the practitioner in medicine can be used to identify obese patients at high risk of NASH, aiming to direct them to specialized medical centers.
Keywords:
Noninvasive Markers; NAFLD; Steatohepatitis; Obesity; Inflammatory markers

Issue: 2018, Volume 69, Issue 6
Pages: 1501-1505
Publication date: 2018/7/15
https://doi.org/10.37358/RC.18.6.6355
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
LIVADARIU, R.M., DANILA, R., IONESCU, L., CIOBANU, D., TIMOFTE, D., Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity, Rev. Chim., 69(6), 2018, 1501-1505.

Vancouver
Livadariu RM, Danila R, Ionescu L, Ciobanu D, Timofte D. Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity. Rev. Chim.[internet]. 2018 Jun;69(6):1501-1505. Available from: https://doi.org/10.37358/RC.18.6.6355


APA 6th edition
Livadariu, R.M., Danila, R., Ionescu, L., Ciobanu, D. & Timofte, D. (2018). Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity. Revista de Chimie, 69(6), 1501-1505. https://doi.org/10.37358/RC.18.6.6355


Harvard
Livadariu, R.M., Danila, R., Ionescu, L., Ciobanu, D., Timofte, D. (2018). 'Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity', Revista de Chimie, 69(6), pp. 1501-1505. https://doi.org/10.37358/RC.18.6.6355


IEEE
R.M. Livadariu, R. Danila, L. Ionescu, D. Ciobanu, D. Timofte, "Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity". Revista de Chimie, vol. 69, no. 6, pp. 1501-1505, 2018. [online]. https://doi.org/10.37358/RC.18.6.6355


Text
Roxana Maria Livadariu, Radu Danila, Lidia Ionescu, Delia Ciobanu, Daniel Timofte,
Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1501-1505,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6355.
(https://revistadechimie.ro/Articles.asp?ID=6355)
Keywords: Noninvasive Markers; NAFLD; Steatohepatitis; Obesity; Inflammatory markers


RIS
TY - JOUR
T1 - Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity
A1 - Livadariu, Roxana Maria
A2 - Danila, Radu
A3 - Ionescu, Lidia
A4 - Ciobanu, Delia
A5 - Timofte, Daniel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1501
EP - 1505
UR - https://doi.org/10.37358/RC.18.6.6355
KW - Noninvasive Markers
KW - NAFLD
KW - Steatohepatitis
KW - Obesity
KW - Inflammatory markers
ER -


BibTex
@article{RevCh2018P1501,
author = {Livadariu Roxana Maria and Danila Radu and Ionescu Lidia and Ciobanu Delia and Timofte Daniel},
title = {Study of Biochemical and Clinical Markers in Steatohepatitis Related to Obesity},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1501-1505},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6355},
url = {https://revistadechimie.ro/Articles.asp?ID=6355}
}
 
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