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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 4, 906-909

https://doi.org/10.37358/RC.18.4.6225

Ionut Cazan, Sidonia Susanu, Otilia Boisteanu, Diana Tatarciuc, Victor Vlad Costan, Marcel Costuleanu

Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro

Abstract:

We tempted to explore the biochemical effects, represented by apoptosis, triggered by conditioned medium, obtained as a result of culturing mesenchymal stem cells for 24 h, on endothelial progenitor cells. The mesenchymal stem cells were developed on collagen fibers in the presence of thapsigargin, concanavalin A, leptin and ghrelin. Meanwhile, were used the following inhibitors: AG490, a JAK2 inhibitor; PD98059, a MEK/ERK inhibitor; and LY294002, a PI3K/Akt signaling inhibitor. When we analyzed the results, we observed that the conditioned medium, obtained from mesenchymal stem cells cultivation, applied in a 10% concentration for 24 H , induced apoptosis of endothelial progenitor cells in different degrees: 10 µM leptin] ghrelin]]concanavalin A @ apelin. Furthermore, LY294002 and AG490-conditioned medium of mesenchymal stem cells reduced the apoptotic effects induced by leptin on developed endothelial progenitor cells. The very first conclusion is that the inhibition of PI3K/Akt signaling pathway is blocking the apoptotic effects of leptin stimulation of mesenchymal stem cells population. The inhibition of JAK/STAT pathways seems to be less effective.
Keywords:
mesenchymal stem cell; endothelial progenitor stem cells; leptin; ghrelin; PI3K/Akt signaling

Issue: 2018, Volume 69, Issue 4
Pages: 906-909
Publication date: 2018/5/15
https://doi.org/10.37358/RC.18.4.6225
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CAZAN, I., SUSANU, S., BOISTEANU, O., TATARCIUC, D., COSTAN, V.V., COSTULEANU, M., Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro, Rev. Chim., 69(4), 2018, 906-909.

Vancouver
Cazan I, Susanu S, Boisteanu O, Tatarciuc D, Costan VV, Costuleanu M. Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro. Rev. Chim.[internet]. 2018 Apr;69(4):906-909. Available from: https://doi.org/10.37358/RC.18.4.6225


APA 6th edition
Cazan, I., Susanu, S., Boisteanu, O., Tatarciuc, D., Costan, V.V. & Costuleanu, M. (2018). Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro. Revista de Chimie, 69(4), 906-909. https://doi.org/10.37358/RC.18.4.6225


Harvard
Cazan, I., Susanu, S., Boisteanu, O., Tatarciuc, D., Costan, V.V., Costuleanu, M. (2018). 'Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro', Revista de Chimie, 69(4), pp. 906-909. https://doi.org/10.37358/RC.18.4.6225


IEEE
I. Cazan, S. Susanu, O. Boisteanu, D. Tatarciuc, V.V. Costan, M. Costuleanu, "Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro". Revista de Chimie, vol. 69, no. 4, pp. 906-909, 2018. [online]. https://doi.org/10.37358/RC.18.4.6225


Text
Ionut Cazan, Sidonia Susanu, Otilia Boisteanu, Diana Tatarciuc, Victor Vlad Costan, Marcel Costuleanu,
Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 906-909,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6225.
(https://revistadechimie.ro/Articles.asp?ID=6225)
Keywords: mesenchymal stem cell; endothelial progenitor stem cells; leptin; ghrelin; PI3K/Akt signaling


RIS
TY - JOUR
T1 - Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro
A1 - Cazan, Ionut
A2 - Susanu, Sidonia
A3 - Boisteanu, Otilia
A4 - Tatarciuc, Diana
A5 - Costan, Victor Vlad
A6 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 906
EP - 909
UR - https://doi.org/10.37358/RC.18.4.6225
KW - mesenchymal stem cell
KW - endothelial progenitor stem cells
KW - leptin
KW - ghrelin
KW - PI3K/Akt signaling
ER -


BibTex
@article{RevCh2018P906,
author = {Cazan Ionut and Susanu Sidonia and Boisteanu Otilia and Tatarciuc Diana and Costan Victor Vlad and Costuleanu Marcel},
title = {Biochemical Effects of Collagen-Cultured Mesenchymal Stem Cells on Endothelial Progenitor Cells In Vitro},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {906-909},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6225},
url = {https://revistadechimie.ro/Articles.asp?ID=6225}
}
 
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