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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 4, 783-789

https://doi.org/10.37358/RC.18.4.6200

Elena Grosu, Ancuta Trifoi, Maria Rapa, Timea Gherman, Andreea Turcanu, Petru Filip

Study of the Drug Diffusion Through Polymeric Membranes

Abstract:

We present the studies carried out on the transport properties of some membranes obtained from synthetic polymers: polyurethane and ethylene-vinyl acetate copolymer, for use in the development of transdermal therapeutic systems with limiting membranes of speed. The properties of drug active substances transport through membranes were highlighted by performing studies with a diffusion cell. Experimental drug active substances were paracetamol and tetracycline. The experimental data obtained was processed using a general mathematical model for drug release from non-porous, non-swellable transdermal devices, which starts from Fick’s second law and has terms that also take into account the possibility of retaining the drug in the membrane polymer. Even though the mathematical model does not take into account neither the swelling phenomenon nor the possibility of membrane erosion, a good agreement between model and experimental data was obtained. The values of effective diffusion coefficients of drug in the polymeric membranes were also determined.
Keywords:
therapeutic transdermal delivery; Fick’s diffusion law; drugs transport through polymeric membranes; modelling

Issue: 2018, Volume 69, Issue 4
Pages: 783-789
Publication date: 2018/5/15
https://doi.org/10.37358/RC.18.4.6200
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
GROSU, E., TRIFOI, A., RAPA, M., GHERMAN, T., TURCANU, A., FILIP, P., Study of the Drug Diffusion Through Polymeric Membranes, Rev. Chim., 69(4), 2018, 783-789.

Vancouver
Grosu E, Trifoi A, Rapa M, Gherman T, Turcanu A, Filip P. Study of the Drug Diffusion Through Polymeric Membranes. Rev. Chim.[internet]. 2018 Apr;69(4):783-789. Available from: https://doi.org/10.37358/RC.18.4.6200


APA 6th edition
Grosu, E., Trifoi, A., Rapa, M., Gherman, T., Turcanu, A. & Filip, P. (2018). Study of the Drug Diffusion Through Polymeric Membranes. Revista de Chimie, 69(4), 783-789. https://doi.org/10.37358/RC.18.4.6200


Harvard
Grosu, E., Trifoi, A., Rapa, M., Gherman, T., Turcanu, A., Filip, P. (2018). 'Study of the Drug Diffusion Through Polymeric Membranes', Revista de Chimie, 69(4), pp. 783-789. https://doi.org/10.37358/RC.18.4.6200


IEEE
E. Grosu, A. Trifoi, M. Rapa, T. Gherman, A. Turcanu, P. Filip, "Study of the Drug Diffusion Through Polymeric Membranes". Revista de Chimie, vol. 69, no. 4, pp. 783-789, 2018. [online]. https://doi.org/10.37358/RC.18.4.6200


Text
Elena Grosu, Ancuta Trifoi, Maria Rapa, Timea Gherman, Andreea Turcanu, Petru Filip,
Study of the Drug Diffusion Through Polymeric Membranes,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 783-789,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6200.
(https://revistadechimie.ro/Articles.asp?ID=6200)
Keywords: therapeutic transdermal delivery; Fick’s diffusion law; drugs transport through polymeric membranes; modelling


RIS
TY - JOUR
T1 - Study of the Drug Diffusion Through Polymeric Membranes
A1 - Grosu, Elena
A2 - Trifoi, Ancuta
A3 - Rapa, Maria
A4 - Gherman, Timea
A5 - Turcanu, Andreea
A6 - Filip, Petru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 783
EP - 789
UR - https://doi.org/10.37358/RC.18.4.6200
KW - therapeutic transdermal delivery
KW - Fick’s diffusion law
KW - drugs transport through polymeric membranes
KW - modelling
ER -


BibTex
@article{RevCh2018P783,
author = {Grosu Elena and Trifoi Ancuta and Rapa Maria and Gherman Timea and Turcanu Andreea and Filip Petru},
title = {Study of the Drug Diffusion Through Polymeric Membranes},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {783-789},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6200},
url = {https://revistadechimie.ro/Articles.asp?ID=6200}
}
 
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