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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 2, 533-538

https://doi.org/10.37358/RC.18.2.6142

Ondrej Hegedus, Zuzana Smotlakova, Alzbeta Hegedusova, Jarmila Dubajova, Alena Andrejiova, Silvia Jakabova, Szende Tonk, Robert Szep, Timea Pernyeszi

Determination of Isocyanates in Workplace Atmosphere by HPLC

Abstract:

Determination of diisocyanates in the laboratories of the Authorities of Public Health was described and verified. Air samples collected in the breathing zone of workers exposed to diisocyanates were analyzed in an automotive industry. Diisocyanates (2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 4,4'-methylenediphenyl isocyanate, and 1,6-hexamethylene diisocyanate) were measured by HPLC and the validation characteristics were determined. Diisocyanate exposure was monitored in the workplace atmosphere of 25 workers. Air samples from the breathing zone were collected and analyzed by HPLC after extraction. The results were compared to the occupational exposure limit. Reliability of the method was confirmed by validation characteristics for the diisocyanates. The repeatability of the method ranged from 2.98 to 4.51%, the calculated relative standard uncertainty was 11 - 12% for the parameters, and the recovery was between 99 and 103%. The low LOD and LOQ ensured the determination of the diisocyanates in the harmful concentration. Monitoring of diisocyanate exposure was performed on four different workplaces. The results showed that 2,4-toluene diisocyanate and 2,6-toluene diisocyanate were present in the concentration range from 6.3 to 13.2 µg m-3. The 1,6-hexamethylene diisocyanate was found in all cases below the limit of detection and the 4,4'-methylenediphenyl isocyanate was found only at two workplaces (between 8.3 and 44.8 µg m-3). The HPLC method was found to be appropriate for the determination of diisocyanates. Applying the method for the determination of diisocyanate exposure in four different workplaces, which produce car accessories, showed that the diisocyanate level did not exceed the occupational exposure limit set for average exposure.
Keywords:
Monitoring of Workplace Atmosphere; Diisocyanates; HPLC; Method Validation

Issue: 2018, Volume 69, Issue 2
Pages: 533-538
Publication date: 2018/3/15
https://doi.org/10.37358/RC.18.2.6142
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
HEGEDUS, O., SMOTLAKOVA, Z., HEGEDUSOVA, A., DUBAJOVA, J., ANDREJIOVA, A., JAKABOVA, S., TONK, S., SZEP, R., PERNYESZI, T., Determination of Isocyanates in Workplace Atmosphere by HPLC, Rev. Chim., 69(2), 2018, 533-538.

Vancouver
Hegedus O, Smotlakova Z, Hegedusova A, Dubajova J, Andrejiova A, Jakabova S, Tonk S, Szep R, Pernyeszi T. Determination of Isocyanates in Workplace Atmosphere by HPLC. Rev. Chim.[internet]. 2018 Feb;69(2):533-538. Available from: https://doi.org/10.37358/RC.18.2.6142


APA 6th edition
Hegedus, O., Smotlakova, Z., Hegedusova, A., Dubajova, J., Andrejiova, A., Jakabova, S.,... Pernyeszi, T. (2018). Determination of Isocyanates in Workplace Atmosphere by HPLC. Revista de Chimie, 69(2), 533-538. https://doi.org/10.37358/RC.18.2.6142


Harvard
Hegedus, O., Smotlakova, Z., Hegedusova, A., Dubajova, J., Andrejiova, A., Jakabova, S., Tonk, S., Szep, R., Pernyeszi, T. (2018). 'Determination of Isocyanates in Workplace Atmosphere by HPLC', Revista de Chimie, 69(2), pp. 533-538. https://doi.org/10.37358/RC.18.2.6142


IEEE
O. Hegedus, Z. Smotlakova, A. Hegedusova, J. Dubajova, A. Andrejiova, S. Jakabova, S. Tonk, R. Szep, T. Pernyeszi, "Determination of Isocyanates in Workplace Atmosphere by HPLC". Revista de Chimie, vol. 69, no. 2, pp. 533-538, 2018. [online]. https://doi.org/10.37358/RC.18.2.6142


Text
Ondrej Hegedus, Zuzana Smotlakova, Alzbeta Hegedusova, Jarmila Dubajova, Alena Andrejiova, Silvia Jakabova, Szende Tonk, Robert Szep, Timea Pernyeszi,
Determination of Isocyanates in Workplace Atmosphere by HPLC,
Revista de Chimie,
Volume 69, Issue 2,
2018,
Pages 533-538,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.2.6142.
(https://revistadechimie.ro/Articles.asp?ID=6142)
Keywords: Monitoring of Workplace Atmosphere; Diisocyanates; HPLC; Method Validation


RIS
TY - JOUR
T1 - Determination of Isocyanates in Workplace Atmosphere by HPLC
A1 - Hegedus, Ondrej
A2 - Smotlakova, Zuzana
A3 - Hegedusova, Alzbeta
A4 - Dubajova, Jarmila
A5 - Andrejiova, Alena
A6 - Jakabova, Silvia
A7 - Tonk, Szende
A8 - Szep, Robert
A9 - Pernyeszi, Timea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 2
SP - 533
EP - 538
UR - https://doi.org/10.37358/RC.18.2.6142
KW - Monitoring of Workplace Atmosphere
KW - Diisocyanates
KW - HPLC
KW - Method Validation
ER -


BibTex
@article{RevCh2018P533,
author = {Hegedus Ondrej and Smotlakova Zuzana and Hegedusova Alzbeta and Dubajova Jarmila and Andrejiova Alena and Jakabova Silvia and Tonk Szende and Szep Robert and Pernyeszi Timea},
title = {Determination of Isocyanates in Workplace Atmosphere by HPLC},
journal = {Revista de Chimie},
volume = {69},
number = {2},
pages = {533-538},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.2.6142},
url = {https://revistadechimie.ro/Articles.asp?ID=6142}
}
 
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