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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 2, 419-428

https://doi.org/10.37358/RC.18.2.6120

Cristian Mesina, Liviu Catalin Stoean, Ruxandra Stoean, Victor Adrian Sandita, Corina Lavinia Gruia, Maria Camelia Foarfa, Luciana Teodora Rotaru, Alina Elena Ciobanu, Mihai Mesina, Veronica Calborean, Victor Gheorman, Daniela Ciobanu

Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps

Abstract:

82 patients, who had been diagnosed with colo-rectal adenocarcinoma in our department between 2007 and 2014, were included in our study. Additionally, 31 patients with colo-rectal polyps (20 conventional adenomatous polyps and 11 malignant colo-rectal polyps) were also included in this study. The patients with colo-rectal adenocarcinoma were reevaluated in terms of gender, age, topography of recto-colic tumor, TNM stadialization, vasculo-lymphatic invasion, lymph nodes metastases and distant metastases. The study of CD8, Ki67, p53, CDX2 and D2-40 immunoexpression in colo-rectal cancer patients revealed: an elevated positivity index in patients with pT2 and pT3 stages and in patients with lymph node metastases in case of the CD8; an elevated positivity index in patients with pT2, pT3 and pT4 stage in case of Ki67; an elevated positivity index in patients with pT4 stage in in case of the p53; an increased positivity index in the pT2, pT3 stage, the absence of vasculo-lymphatic invasion, the absence of lymph node and distant metastases in case of the CDX2 and an increased positivity index in patients with the pT2, pT3 stage, the abscence of lymph node and distant metastases in case of the D2-40 Tumoral staging (pT2, pT3 and pT4) has been shown to be correlated with immunoexpression of the following markers: CD8, CDX2 and p53.
Keywords:
CD8; CDX2; D2-40; distant metastases; Ki-67; lymph node metastases; p53; vasculo-lymphatic invasion

Issue: 2018, Volume 69, Issue 2
Pages: 419-428
Publication date: 2018/3/15
https://doi.org/10.37358/RC.18.2.6120
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MESINA, C., STOEAN, L.C., STOEAN, R., SANDITA, V.A., GRUIA, C.L., FOARFA, M.C., ROTARU, L.T., CIOBANU, A.E., MESINA, M., CALBOREAN, V., GHEORMAN, V., CIOBANU, D., Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps, Rev. Chim., 69(2), 2018, 419-428.

Vancouver
Mesina C, Stoean LC, Stoean R, Sandita VA, Gruia CL, Foarfa MC, Rotaru LT, Ciobanu AE, Mesina M, Calborean V, Gheorman V, Ciobanu D. Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps. Rev. Chim.[internet]. 2018 Feb;69(2):419-428. Available from: https://doi.org/10.37358/RC.18.2.6120


APA 6th edition
Mesina, C., Stoean, L.C., Stoean, R., Sandita, V.A., Gruia, C.L., Foarfa, M.C.,... Ciobanu, D. (2018). Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps. Revista de Chimie, 69(2), 419-428. https://doi.org/10.37358/RC.18.2.6120


Harvard
Mesina, C., Stoean, L.C., Stoean, R., Sandita, V.A., Gruia, C.L., Foarfa, M.C., Rotaru, L.T., Ciobanu, A.E., Mesina, M., Calborean, V., Gheorman, V., Ciobanu, D. (2018). 'Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps', Revista de Chimie, 69(2), pp. 419-428. https://doi.org/10.37358/RC.18.2.6120


IEEE
C. Mesina, L.C. Stoean, R. Stoean, V.A. Sandita, C.L. Gruia, M.C. Foarfa, L.T. Rotaru, A.E. Ciobanu, M. Mesina, V. Calborean, V. Gheorman, D. Ciobanu, "Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps". Revista de Chimie, vol. 69, no. 2, pp. 419-428, 2018. [online]. https://doi.org/10.37358/RC.18.2.6120


Text
Cristian Mesina, Liviu Catalin Stoean, Ruxandra Stoean, Victor Adrian Sandita, Corina Lavinia Gruia, Maria Camelia Foarfa, Luciana Teodora Rotaru, Alina Elena Ciobanu, Mihai Mesina, Veronica Calborean, Victor Gheorman, Daniela Ciobanu,
Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps,
Revista de Chimie,
Volume 69, Issue 2,
2018,
Pages 419-428,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.2.6120.
(https://revistadechimie.ro/Articles.asp?ID=6120)
Keywords: CD8; CDX2; D2-40; distant metastases; Ki-67; lymph node metastases; p53; vasculo-lymphatic invasion


RIS
TY - JOUR
T1 - Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps
A1 - Mesina, Cristian
A2 - Stoean, Liviu Catalin
A3 - Stoean, Ruxandra
A4 - Sandita, Victor Adrian
A5 - Gruia, Corina Lavinia
A6 - Foarfa, Maria Camelia
A7 - Rotaru, Luciana Teodora
A8 - Ciobanu, Alina Elena
A9 - Mesina, Mihai
A10 - Calborean, Veronica
A11 - Gheorman, Victor
A12 - Ciobanu, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 2
SP - 419
EP - 428
UR - https://doi.org/10.37358/RC.18.2.6120
KW - CD8
KW - CDX2
KW - D2-40
KW - distant metastases
KW - Ki-67
KW - lymph node metastases
KW - p53
KW - vasculo-lymphatic invasion
ER -


BibTex
@article{RevCh2018P419,
author = {Mesina Cristian and Stoean Liviu Catalin and Stoean Ruxandra and Sandita Victor Adrian and Gruia Corina Lavinia and Foarfa Maria Camelia and Rotaru Luciana Teodora and Ciobanu Alina Elena and Mesina Mihai and Calborean Veronica and Gheorman Victor and Ciobanu Daniela},
title = {Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps},
journal = {Revista de Chimie},
volume = {69},
number = {2},
pages = {419-428},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.2.6120},
url = {https://revistadechimie.ro/Articles.asp?ID=6120}
}
 
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