HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products

Nita, Adriana; Tit, Delia Mirela; Copolovici, Lucian; Melinte (Frunzulica), Carmen Elena; Copolovici, Dana Maria; Bungau, Simona; Iovan, Ciprian

Adriana Nita, Delia Mirela Tit, Lucian Copolovici, Carmen Elena Melinte (Frunzulica), Dana Maria Copolovici, Simona Bungau, Ciprian Iovan

HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products

Abstract:

The aim of this study was to develop and validate a rapid, accurate, and exact method for the quantitative determination of famotidine in pharmaceutical products. The HPLC analyses were performed by using a mobile phase containing methanol:1% acetic acid solution=30:7 (v/v), at a flow rate of 0.4 mL/min.The total time of the method was 10 min, and the retention time of famotidine was 4.16 min. The detection was evaluated at l=267 nm. The method has been validated by using different validation parameters. The linear response of the detector for famotidine peak area was observed at concentrations ranging from 0.1 to 0.0001 mg mL-1 , resulting in a correlation coefficient of 0.99998. The values of the detection limit and of the quantification limit are 0.00048 mg mL-1 and 0.00148 mg mL-1, respectively. The method proposed allowed accurate (with a relative error of less than 2%) and precise (RSD values less than 2.0%) determination of famotidine content in pharmaceutical products and can be used for its rapid quantitative analysis.

Keywords:
famotidine; HPLC-UV; pharmaceutical products

Issue: 2018, Volume 69, Issue 2

Pages: 297-299

Publication date: 2018/3/15

https://doi.org/10.37358/RC.18.2.6093

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Citation Styles

Cite this article as:
NITA, A., TIT, D.M., COPOLOVICI, L., MELINTE (FRUNZULICA), C.E., COPOLOVICI, D.M., BUNGAU, S., IOVAN, C., HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products, Rev. Chim., 69(2), 2018, 297-299.

Vancouver
Nita A, Tit DM, Copolovici L, Melinte (Frunzulica) CE, Copolovici DM, Bungau S, Iovan C. HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products. Rev. Chim.[internet]. 2018 Feb;69(2):297-299. Available from: https://doi.org/10.37358/RC.18.2.6093

APA 6th edition
Nita, A., Tit, D.M., Copolovici, L., Melinte (Frunzulica), C.E., Copolovici, D.M., Bungau, S. & Iovan, C. (2018). HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products. Revista de Chimie, 69(2), 297-299. https://doi.org/10.37358/RC.18.2.6093

Harvard
Nita, A., Tit, D.M., Copolovici, L., Melinte (Frunzulica), C.E., Copolovici, D.M., Bungau, S., Iovan, C. (2018). 'HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products', Revista de Chimie, 69(2), pp. 297-299. https://doi.org/10.37358/RC.18.2.6093

IEEE
A. Nita, D.M. Tit, L. Copolovici, C.E. Melinte(Frunzulica), D.M. Copolovici, S. Bungau, C. Iovan, "HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products". Revista de Chimie, vol. 69, no. 2, pp. 297-299, 2018. [online]. https://doi.org/10.37358/RC.18.2.6093

Text
Adriana Nita, Delia Mirela Tit, Lucian Copolovici, Carmen Elena Melinte(Frunzulica), Dana Maria Copolovici, Simona Bungau, Ciprian Iovan,
HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products,
Revista de Chimie,
Volume 69, Issue 2,
2018,
Pages 297-299,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.2.6093.
(https://revistadechimie.ro/Articles.asp?ID=6093)
Keywords: famotidine; HPLC-UV; pharmaceutical products

RIS
TY - JOUR
T1 - HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products
A1 - Nita, Adriana
A2 - Tit, Delia Mirela
A3 - Copolovici, Lucian
A4 - Melinte (Frunzulica), Carmen Elena
A5 - Copolovici, Dana Maria
A6 - Bungau, Simona
A7 - Iovan, Ciprian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 2
SP - 297
EP - 299
UR - https://doi.org/10.37358/RC.18.2.6093
KW - famotidine
KW - HPLC-UV
KW - pharmaceutical products
ER -

BibTex
@article{RevCh2018P297,
author = {Nita Adriana and Tit Delia Mirela and Copolovici Lucian and Melinte (Frunzulica) Carmen Elena and Copolovici Dana Maria and Bungau Simona and Iovan Ciprian},
title = {HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products},
journal = {Revista de Chimie},
volume = {69},
number = {2},
pages = {297-299},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.2.6093},
url = {https://revistadechimie.ro/Articles.asp?ID=6093}
}

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