Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

Stefan, Diana Simona; Mihai, Andrada; Bajko, Daiana; Lixandru, Daniela; Petcu, Laura; Picu, Ariana; Smeu, Bogdan; Copaescu, Catalin; Tirgoviste, Constantin Ionescu; Guja, Cristian

Diana Simona Stefan, Andrada Mihai, Daiana Bajko, Daniela Lixandru, Laura Petcu, Ariana Picu, Bogdan Smeu, Catalin Copaescu, Constantin Ionescu Tirgoviste, Cristian Guja

Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

Abstract:

Metabolic surgery is the most efficacious method for the treatment of morbid obesity and was recently included among the antidiabetes treatments recommended in obese type 2 diabetes (T2D) patients. The aim of this study was to compare in a randomized controlled trial the effect of sleeve gastrectomy (SG) to that of intensive lifestyle intervention plus pharmacologic treatment on some markers of insulin resistance and beta cell function as well as some appetite controlling hormones in a group of male obese T2D subjects. The study groups comprised 20 subjects for SG and 21 control subjects. Fasting blood glucose, insulin, proinsulin, adiponectin, leptin, ghrelin, HOMA-IR, HOMA-%B, proinsulin-to-insulin ratio and proinsulin-to-adiponectin ratio were evaluated at baseline and after one year follow-up. Overall, patients in the SG group lost 78.98% of excess weight loss (%EWL) in comparison with 9.45% in the control group. This was accompanied by a significant improvement of insulin resistance markers, including increase of adiponectin and decrease of HOMA-IR, while no changes were recorded in the control group. Weight loss was also associated with a significant improvement of proinsulin-to-insulin and proinsulin-to-adiponectin ratio, both surrogate markers of beta cell dysfunction. These also improved in the control group, but were only marginally significant. Our findings suggest that improved insulin resistance and decreased beta cell dysfunction after sleeve gastrectomy might explain diabetes remission associated with metabolic surgery.

Keywords:
hormones; obesity; diabetes; weight loss; lifestyle intervention; sleeve gastrectomy

Issue: 2017, Volume 68, Issue 7

Pages: 1622-1627

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5730

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STEFAN, D.S., MIHAI, A., BAJKO, D., LIXANDRU, D., PETCU, L., PICU, A., SMEU, B., COPAESCU, C., TIRGOVISTE, C.I., GUJA, C., Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results, Rev. Chim., 68(7), 2017, 1622-1627.

Vancouver
Stefan DS, Mihai A, Bajko D, Lixandru D, Petcu L, Picu A, Smeu B, Copaescu C, Tirgoviste CI, Guja C. Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results. Rev. Chim.[internet]. 2017 Jul;68(7):1622-1627. Available from: https://doi.org/10.37358/RC.17.7.5730

APA 6th edition
Stefan, D.S., Mihai, A., Bajko, D., Lixandru, D., Petcu, L., Picu, A.,... Guja, C. (2017). Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results. Revista de Chimie, 68(7), 1622-1627. https://doi.org/10.37358/RC.17.7.5730

Harvard
Stefan, D.S., Mihai, A., Bajko, D., Lixandru, D., Petcu, L., Picu, A., Smeu, B., Copaescu, C., Tirgoviste, C.I., Guja, C. (2017). 'Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results', Revista de Chimie, 68(7), pp. 1622-1627. https://doi.org/10.37358/RC.17.7.5730

IEEE
D.S. Stefan, A. Mihai, D. Bajko, D. Lixandru, L. Petcu, A. Picu, B. Smeu, C. Copaescu, C.I. Tirgoviste, C. Guja, "Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results". Revista de Chimie, vol. 68, no. 7, pp. 1622-1627, 2017. [online]. https://doi.org/10.37358/RC.17.7.5730

Text
Diana Simona Stefan, Andrada Mihai, Daiana Bajko, Daniela Lixandru, Laura Petcu, Ariana Picu, Bogdan Smeu, Catalin Copaescu, Constantin Ionescu Tirgoviste, Cristian Guja,
Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1622-1627,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5730.
(https://revistadechimie.ro/Articles.asp?ID=5730)
Keywords: hormones; obesity; diabetes; weight loss; lifestyle intervention; sleeve gastrectomy

RIS
TY - JOUR
T1 - Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results
A1 - Stefan, Diana Simona
A2 - Mihai, Andrada
A3 - Bajko, Daiana
A4 - Lixandru, Daniela
A5 - Petcu, Laura
A6 - Picu, Ariana
A7 - Smeu, Bogdan
A8 - Copaescu, Catalin
A9 - Tirgoviste, Constantin Ionescu
A10 - Guja, Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1622
EP - 1627
UR - https://doi.org/10.37358/RC.17.7.5730
KW - hormones
KW - obesity
KW - diabetes
KW - weight loss
KW - lifestyle intervention
KW - sleeve gastrectomy
ER -

BibTex
@article{RevCh2017P1622,
author = {Stefan Diana Simona and Mihai Andrada and Bajko Daiana and Lixandru Daniela and Petcu Laura and Picu Ariana and Smeu Bogdan and Copaescu Catalin and Tirgoviste Constantin Ionescu and Guja Cristian},
title = {Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1622-1627},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5730},
url = {https://revistadechimie.ro/Articles.asp?ID=5730}
}

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