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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 2, 369-372

https://doi.org/10.37358/RC.17.2.5455

Codrina Ancuta, Eugen Ancuta, Rodica Chirieac, Magda Antohe, Cristina Iordache

Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach

Abstract:

Although the relationship between periodontal disease and rheumatoid arthritis (RA) is widely documented, centered by common pathobiologic pathways, the effect of various tumor necrosis factor alpha (TNF) antagonists in modulating not only inflammatory and immune articular damage, but also periodontal microenvironment remain debatable. We aimed to evaluate the periodontal status with and without TNF inhibitors in RA patients and to identify potential relation among these entities. We performed a prospective longitudinal 6-months analysis on 96 RA initiating their first biological therapy. Standard assessments included a dual rheumatologic (RA activity, disability, serological, inflammatory prolife) and dental evaluation such as plaque index (PI), gingival index (GI), bleeding on probing (BOP), pocket depth (PD), clinical attachment level (CAL). More than half of RA presented at baseline with chronic periodontitis, as suggested by high prevalence of sites with dental plaque, abnormal BOP, PD and CAL. Advanced inflammatory (CRP, ESR) and immune (anti-cyclic citrullinated peptide antibodies, ACPA) markers were described in RA subsets presenting with aggressive periodontal diseases, while significant correlations between dental pathology, RA activity and ACPA levels were also reported (p[0.05). Furthermore, we revealed significant improvement in both RA-related characteristics and periodontal status after 6 months of anti-TNF therapy (p[0.05). RA, particularly active severe, ACPA positive disease, is essentially accompanied by comorbid periodontal disease. TNF blockade is efficient in patients with active RA and potentially able to modulate the inflammatory process in the periodontal tissue.
Keywords:
rheumatoid arthritis; periodontal disease; TNF inhibitors; anti-cyclic citrullinated peptide antibodies

Issue: 2017, Volume 68, Issue 2
Pages: 369-372
Publication date: 2017/3/15
https://doi.org/10.37358/RC.17.2.5455
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ANCUTA, C., ANCUTA, E., CHIRIEAC, R., ANTOHE, M., IORDACHE, C., Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach, Rev. Chim., 68(2), 2017, 369-372.

Vancouver
Ancuta C, Ancuta E, Chirieac R, Antohe M, Iordache C. Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach. Rev. Chim.[internet]. 2017 Feb;68(2):369-372. Available from: https://doi.org/10.37358/RC.17.2.5455


APA 6th edition
Ancuta, C., Ancuta, E., Chirieac, R., Antohe, M. & Iordache, C. (2017). Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach. Revista de Chimie, 68(2), 369-372. https://doi.org/10.37358/RC.17.2.5455


Harvard
Ancuta, C., Ancuta, E., Chirieac, R., Antohe, M., Iordache, C. (2017). 'Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach', Revista de Chimie, 68(2), pp. 369-372. https://doi.org/10.37358/RC.17.2.5455


IEEE
C. Ancuta, E. Ancuta, R. Chirieac, M. Antohe, C. Iordache, "Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach". Revista de Chimie, vol. 68, no. 2, pp. 369-372, 2017. [online]. https://doi.org/10.37358/RC.17.2.5455


Text
Codrina Ancuta, Eugen Ancuta, Rodica Chirieac, Magda Antohe, Cristina Iordache,
Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach,
Revista de Chimie,
Volume 68, Issue 2,
2017,
Pages 369-372,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.2.5455.
(https://revistadechimie.ro/Articles.asp?ID=5455)
Keywords: rheumatoid arthritis; periodontal disease; TNF inhibitors; anti-cyclic citrullinated peptide antibodies


RIS
TY - JOUR
T1 - Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach
A1 - Ancuta, Codrina
A2 - Ancuta, Eugen
A3 - Chirieac, Rodica
A4 - Antohe, Magda
A5 - Iordache, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 2
SP - 369
EP - 372
UR - https://doi.org/10.37358/RC.17.2.5455
KW - rheumatoid arthritis
KW - periodontal disease
KW - TNF inhibitors
KW - anti-cyclic citrullinated peptide antibodies
ER -


BibTex
@article{RevCh2017P369,
author = {Ancuta Codrina and Ancuta Eugen and Chirieac Rodica and Antohe Magda and Iordache Cristina},
title = {Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach},
journal = {Revista de Chimie},
volume = {68},
number = {2},
pages = {369-372},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.2.5455},
url = {https://revistadechimie.ro/Articles.asp?ID=5455}
}
 
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