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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 2, 354-357

https://doi.org/10.37358/RC.17.2.5452

Andrei Niculae, Cristiana David, Razvan Florin Ion Dragomirescu, Ileana Peride, Flavia Liliana Turcu, Lucian Cristian Petcu, Adrian Covic, Ionel Alexandru Checherita

Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients

Abstract:

Once recombinant human erythropoietin (r-HuEPO) was introduced in daily practice, huge steps were made in combating the adverse effects induced by anemia in chronic kidney disease population. Still, r-HuEPO resistance and the doses ensuring the maximum therapeutic benefit remain matters of debate. The aim of our study was to assess the correlation between the presence and the degree of inflammation and the r-HuEPO requirements in chronic dialysis patients. We conducted a 2 years prospective study on 146 patients undergoing chronic dialysis treated with r-HuEPO. Based on their average CRP (C-reactive protein) levels, obtained from repeated samplings at 3 months interval, 3 groups were formed; we noted in each group the average values of r-HuEPO prescribed to achieve the optimum hemoglobin levels according to the dialysis best practice guidelines and all the adverse effects of the therapy. A direct correlation was observed between CRP levels and r-HuEPO requirements in the first 2 groups of patients (CRP under 6 mg/L and CRP values 6-20 mg/L), with significant increase in r-HuEPO doses between groups (p [ 0.001); the third group, CRP values over 20 mg/dL, showed a minor, insignificant increase in average r-HuEPO doses compared to mild inflammation group (p = 0.199) and more adverse effects of the therapy (p [ 0.05). Inflammation is an important determinant of anemia in chronic dialysis patients and can induce an increase in the doses of r-HuEPO. However, prescribing excessive r-HuEPO doses is not the answer in severe inflammatory status, due to lack of response and possible adverse effects.
Keywords:
erythropoietin dose; inflammation; chronic dialysis

Issue: 2017, Volume 68, Issue 2
Pages: 354-357
Publication date: 2017/3/15
https://doi.org/10.37358/RC.17.2.5452
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
NICULAE, A., DAVID, C., DRAGOMIRESCU, R.F.I., PERIDE, I., TURCU, F.L., PETCU, L.C., COVIC, A., CHECHERITA, I.A., Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients, Rev. Chim., 68(2), 2017, 354-357.

Vancouver
Niculae A, David C, Dragomirescu RFI, Peride I, Turcu FL, Petcu LC, Covic A, Checherita IA. Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients. Rev. Chim.[internet]. 2017 Feb;68(2):354-357. Available from: https://doi.org/10.37358/RC.17.2.5452


APA 6th edition
Niculae, A., David, C., Dragomirescu, R.F.I., Peride, I., Turcu, F.L., Petcu, L.C., Covic, A. & Checherita, I.A. (2017). Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients. Revista de Chimie, 68(2), 354-357. https://doi.org/10.37358/RC.17.2.5452


Harvard
Niculae, A., David, C., Dragomirescu, R.F.I., Peride, I., Turcu, F.L., Petcu, L.C., Covic, A., Checherita, I.A. (2017). 'Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients', Revista de Chimie, 68(2), pp. 354-357. https://doi.org/10.37358/RC.17.2.5452


IEEE
A. Niculae, C. David, R.F.I. Dragomirescu, I. Peride, F.L. Turcu, L.C. Petcu, A. Covic, I.A. Checherita, "Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients". Revista de Chimie, vol. 68, no. 2, pp. 354-357, 2017. [online]. https://doi.org/10.37358/RC.17.2.5452


Text
Andrei Niculae, Cristiana David, Razvan Florin Ion Dragomirescu, Ileana Peride, Flavia Liliana Turcu, Lucian Cristian Petcu, Adrian Covic, Ionel Alexandru Checherita,
Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients,
Revista de Chimie,
Volume 68, Issue 2,
2017,
Pages 354-357,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.2.5452.
(https://revistadechimie.ro/Articles.asp?ID=5452)
Keywords: erythropoietin dose; inflammation; chronic dialysis


RIS
TY - JOUR
T1 - Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients
A1 - Niculae, Andrei
A2 - David, Cristiana
A3 - Dragomirescu, Razvan Florin Ion
A4 - Peride, Ileana
A5 - Turcu, Flavia Liliana
A6 - Petcu, Lucian Cristian
A7 - Covic, Adrian
A8 - Checherita, Ionel Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 2
SP - 354
EP - 357
UR - https://doi.org/10.37358/RC.17.2.5452
KW - erythropoietin dose
KW - inflammation
KW - chronic dialysis
ER -


BibTex
@article{RevCh2017P354,
author = {Niculae Andrei and David Cristiana and Dragomirescu Razvan Florin Ion and Peride Ileana and Turcu Flavia Liliana and Petcu Lucian Cristian and Covic Adrian and Checherita Ionel Alexandru},
title = {Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients},
journal = {Revista de Chimie},
volume = {68},
number = {2},
pages = {354-357},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.2.5452},
url = {https://revistadechimie.ro/Articles.asp?ID=5452}
}
 
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