Ioana ScrobotA, Camelia Alb, Horia Calniceanu, Grigore Baciut, Ioana Berindan Neagoe, Doina Onisei, Amina Ramona Popovici, Roxana Buzatu, Pompei Bolfa<br>Assessment of Serum Lipid Peroxidation and Redox Thiol System<br>Status in Different Stages of Oral Carcinogenesis

Ioana ScrobotA, Camelia Alb, Horia Calniceanu, Grigore Baciut, Ioana Berindan Neagoe, Doina Onisei, Amina Ramona Popovici, Roxana Buzatu, Pompei Bolfa
Assessment of Serum Lipid Peroxidation and Redox Thiol System
Status in Different Stages of Oral Carcinogenesis

Abstract:

In this study we aimed to monitor serum lipid peroxidation and thiol redox status as indicators of oxidative stress (OS) at different moments during oral carcinogenesis. We evaluated serum malondialdehyde (MDA) and reduced glutathione (GSH) at 12 weeks and 24 weeks of 4NQO induced oral carcinogenesis in Wistar rats. MDA was significantly elevated and GSH significantly reduced (p[0.05) after 12 weeks of carcinogen exposure indicating the installation of OS. From week 12 to week 24 only serum GSH was modified significantly (p[0.05) probably used by the carcinogenetic cells to improve their viability. This modification indicates the disruption in the thiol redox status and persistence of OS even in the absence of increased MDA. Biochemical alterations were associated with oral mucosal dysplastic lesions. Our results support the recent “redox theory” of oxidative stress (OS) and emphasizes the necessity for clarifying the networks involved in OS-mediated carcinogenesis. Such evidence could set the basis in developing new targeted therapeutic protocols to improve the prognostic of oral cancer. Key words: oral carcinogenesis, lipid peroxidation, redox thiol system status

Issue: 2015, Volume 66, Issue 9

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