RICA BOSCENCU, RADU SOCOTEANU, MIHAELA ILIE, ANABELA SOUSA OLIVEIRA4, CAROLINA CONSTANTIN LUIS FILIPE VIEIRA FERREIRA SYNTHESIS, SPECTRAL AND BIOLOGICAL EVALUATION OF SOME MESOPORPHYRINIC ZN(II) COMPLEXES 5-(3-hydroxyphenyl)-10, 15, 20–tris-(4-carboxymethylphenyl)–21, 23 Zn(II) porphine TCMPOHmZn(II) and 5, 10, 15, 20–tetrakis-(4-carboxymethylphenyl)–21, 23 Zn(II) TCMOPZn(II) porphine were obtained through the efficient microwave-assisted methodology in order to further investigation of the theoretical and preclinical aspects of their use as sensitizers in photodynamic therapy (PDT). The complexes were characterized by FTIR, 1H-NMR, 13C-NMR, UV-Visible spectroscopy and their structure was completely confirmed. The spectral molecular absorption properties of the porphyrinic complexes were studied in organic solvents (MeOH, EtOH, Iso-PrOH, DMSO, DMF and CH2Cl2), and the influence of the solvent polarity on the absorption band maxima was evaluated. Cytototoxicity in vitro preliminary studies of the compounds were also performed on the MCF7 and B16 cell lines.
Keywords: asymmetric porphyrins, Zn(II) porphyrin complexes, microvawe, FTIR, UV-Vis, NMR spectroscopy, sensitizers for photodynamic therapy, in vitro, cytotoxicity
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SOCIETATEA DE CHIMIE DIN ROMANIA
SC BIBLIOTECA CHIMIEI SA